PubMed Применение у детей

Обзорные статьи

Mason, Keira P.

Review article: Dexmedetomidine in children: current knowledge and future applications.

Anesthesia and analgesia, 2011, V.113 (№ 5), Р. 1129-42


Mahmoud M, Mason KP.

Dexmedetomidine: review, update, and future considerations of paediatric perioperative and periprocedural applications and limitations. Br J Anaesth. 2015; 115(2): 171-82.


Plambech MZ, Afshari A.

Dexmedetomidine in the pediatric population: a review.  Minerva Anesesiol. 2015; 81(3): 320-32. Epub 2014 May 14.


Hartman ME, McCrory DC, Schulman SR.

Efficacy of sedation regimens to facilitate mechanical ventilation in the pediatric intensive care unit: a systematic review.  Pediatr Crit Care Med 2009; 10 (2),:246-255 (systematic review with section on Dex)



Tu Z, Tan X et al.

The Efficacy and Safety of Dexmedetomidine Combined with Bupivacaine on Caudal Epidural Block in Children: A Meta-Analysis. Med Sci Monit. 2019 Jan 7;25:165-173


Pan W, Wang Y, Lin L, et al.

Outcomes of dexmedetomidine treatment in pediatric patients undergoing congenital heart disease surgery: a meta-analysis. Paediatr Anaesth. 2016; 26(3): 239-48


Pasin L, Febres D, Testa V, et al.

Dexmedetomidine vs midazolam as preanesthetic medication in children: a meta-analysis of randomized controlled trials. Paediatr Anaesth. 2015; 25(5): 468-76.


Ni J, Wei J, Yao Y, et al.

Effect of dexmedetomidine on preventing postoperative agitation in children: a meta-analysis.

PLoS One. 2015 May 21;10(5):e0128450.


Zhu M, Wang H, Zhu A, et al.

Meta-analysis of dexmedetomidine on emergence agitation and recovery profiles in children after sevoflurane anesthesia: different administration and different dosage. PLoS One. 2015 Apr 13;10(4):e0123728.


Pickard A, Davies P, Birnie K et al.

Systematic review and meta-analysis of the effect of intraoperative α₂-adrenergic agonists on postoperative behaviour in children. Br J Anaesth. 2014; 112(6): 982-90.


Sun L, Guo R, Sun L.

Dexmedetomidine for preventing sevoflurane-related emergence agitation in children: a meta-analysis of randomized controlled trials. Acta Anaesthesiol Scand. 2014 Jul;58(6):642-50.


Schnabel A, Reichl SU, Poepping DM, et al.

Efficacy and safety of intraoperative dexmedetomidine for acute postoperative pain in children: a meta-analysis of randomized controlled trials. Paediatr Anaesth. 2013 Feb; 23(2):170-9.


Седация в ОРИТ


Whalen LD, Di Gennaro JL, Irby GA, et al.

Long-term dexmedetomidine use and safety profile among critically ill children and neonates. Pediatr Crit Care Med. 2014; 15(8): 706-14.


Fagin A, Palmieri T, Greenhalgh D et al.

A comparison of dexmedetomidine and midazolam for sedation in severe pediatric burn injury.

J Burn Care Res. 2012; 33(6): 759-63.


Czaja AS,  Zimmerman, JJ

The use of dexmedetomidine in critically ill children.  Pediatr Crit Care Med 2009; 10: 381–6.


Carroll CL, Krieger D, Campbell M, et al.

Use of dexmedetomidine for sedation of children hospitalized in the intensive care unit.

J Hosp Med. 2008; 3: 142-7.



Jones JS, Cotugno RE, Singhal NR, et al.

Evaluation of dexmedetomidine and postoperative pain management in patients with adolescent idiopathic scoliosis: conclusions based on a retrospective study at a tertiary pediatric hospital.

Pediatr Crit Care Med. 2014 Jul;15(6):e247-52.


Patel A, Davidson M, Tran MCJ, et al.

Dexmedetomidine infusion for analgesia and prevention of emergence agitation in children with obstructive sleep apnea syndrome undergoing tonsillectomy and adenoidectomy. Anesth Analg. 2010; 111: 1004-10.



Makkar JK, Bhatia N, Bala I, et al.

A comparison of single dose dexmedetomidine with propofol for the prevention of emergence delirium after desflurane anaesthesia in children. Anaesthesia. 2016 Jan; 71(1): 50-7


Bong CL, Lim E, Allen JC et al.

A comparison of single-dose dexmedetomidine or propofol on the incidence of emergence delirium in children undergoing general anaesthesia for magnetic resonance imaging. Anaesthesia. 2015; 70(4):393-9. Epub 2014 Oct 14.


Turkel SB,  Hanft A. 

The pharmacologic management of delirium in children and adolescents. Paediatr Drugs. 2014; 16(4):267-74. doi: 10.1007/s40272-014-0078-0.


Yang S, Lee H.

A dose-finding study of preoperative intravenous dexmedetomidine in children's emergence delirium after epiblepharon surgery. Eur J Ophthalmol. 2014; 24(3): 417-23. Epub 2013 Nov 29.


Dahmani S, Delivet H, Hilly J.

Emergence delirium in children: an update.  Curr Opin Anaesthesiol. 2014; 27(3): 309-15.


Aydogan MS, Korkmaz MF, Ozgül U, et al. 

Pain, fentanyl consumption, and delirium in adolescents after scoliosis surgery: dexmedetomidine vs midazolam. Paediatr Anaesth. 2013; 23(5): 446-52.


Синдром отмены

Oschman A, McCabe T, Kuhn RJ.

Dexmedetomidine for opioid and benzodiazepine withdrawal in pediatric patients. Am J Health Syst Pharm. 2011;68:1233-8


Tobias JD.

Dexmedetomidine to treat opioid withdrawal in infants following prolonged sedation in the pediatric ICU.  J Opioid Manag. 2006;2:201-5.



Su F, Gastonguay MR, Nicolson SC, et al.

Dexmedetomidine Pharmacology in Neonates and Infants After Open Heart Surgery

Anesth Analg. 2016; 122(5): 1556-66.


Chrysostomou C, Schulman SR, Castellanos MH  et al.

 A phase II/III, multicenter, safety, efficacy, and pharmacokinetic study of dexmedetomidine in preterm and term neonates. J Pediatr. 2014 Feb; 164(2):276-82.e1-3.


Potts AL, Anderson BJ, Warman GR et al.

Dexmedetomidine pharmacokinetics in pediatric intensive care – a pooled analysis.  Paediatr Anaesth. 2009; 19: 1119-29.


Vilo S, Rautiainen P, Kaisti K et al.

Pharmacokinetics of intravenous dexmedetomidine in children under 11 yr of age.

Br J Anaesth. 2008; 100: 697-700.




Kwiatkowski DM, Axelrod DM, Sutherland SM, et al.

Dexmedetomidine Is Associated With Lower Incidence of Acute Kidney Injury After Congenital Heart Surgery. Pediatr Crit Care Med. 2016 Feb;17(2):128-34


Bayram A, Ulgey A, Baykan A et al. 

The effects of dexmedetomidine on early stage renal functions in pediatric patients undergoing cardiac angiography using non-ionic contrast media: a double-blind, randomized clinical trial. Paediatr Anaesth. 2014 Apr; 24(4):426-32.



Cheng X, Zuo Y, Zhao Q, et al.

Comparison of the Effects of Dexmedetomidine and Propofol on Hemodynamics and Oxygen Balance in Children with Complex Congenital Heart Disease Undergoing Cardiac Surgery.

Congenit Heart Dis. 2015; 10(3): E123-30.


Mason KP, Turner DP, Houle TT, et al.

Hemodynamic response to fluid management in children undergoing dexmedetomidine sedation for MRI. AJR Am J Roentgenol. 2014 Jun;202(6):W574-9.


Shank ES, Sheridan RL, Ryan CM, et al. 

Hemodynamic responses to dexmedetomidine in critically injured intubated pediatric burned patients: a preliminary study. J Burn Care Res. 2013 May-Jun;34(3):311-7.


Lam F, Bhutta AT, Tobias JD, et al. 

Hemodynamic effects of dexmedetomidine in critically ill neonates and infants with heart disease. Pediatr Cardiol. 2012 Oct;33(7):1069-77.


Klamt JG, Vicente WV, Garcia LV, et al.

Hemodynamic effects of the combination of dexmedetomidine-fentanyl versus midazolam-fentanyl in children undergoing cardiac surgery with cardiopulmonary bypass. Rev Bras Anestesiol. 2010;60:350-62.


Potts AL, Anderson BJ, Holford NH, et al.

Dexmedetomidine hemodynamics in children after cardiac surgery. Paediatr Anaesth. 2010;20:425-33.


Сердечно-сосудистая система


Gong J, Zhang R et al.

The brain protective effect of dexmedetomidine during surgery for paediatric patients with congenital heart disease. J Int Med Res. 2019 Apr;47(4):1677-1684. doi: 10.1177/0300060518821272.


Ergul Y, Unsal S, Ozyilmaz I, et al.

Electrocardiographic and electrophysiologic effects of dexmedetomidine on children.

Pacing Clin Electrophysiol. 2015; 38(6): 682-7.


Cummings BM, Cowl AS, Yager PH, et al.

Cardiovascular Effects of Continuous Dexmedetomidine Infusion Without a Loading Dose in the Pediatric Intensive Care Unit. J Intensive Care Med. 2015 Dec;30(8):512-7.


Achuff BJ, Nicolson SC, Elci OU, Zuppa AF.

Intraoperative Dexmedetomidine Reduces Postoperative Mechanical Ventilation in Infants After Open Heart Surgery. Pediatr Crit Care Med. 2015; 16(5): 440-7.


 Wong J, Steil GM, Curtis M, et al.

Cardiovascular Effects of Dexmedetomidine Sedation in Children. Anesth Analg. 2012 Jan; 114(1):193-9.


Tobias JD, Gupta P, Naguib A et al.

Dexmedetomidine: applications for the pediatric patient with congenital heart disease.

Pediatr Cardiol. 2011;32: 1075-87.


Chrysostomou C, Komarlu R, Lichtenstein S, et al.

Electrocardiographic effects of dexmedetomidine in patients with congenital heart disease.

Intensive Care Med. 2010;36: 836-42.


Klamt JG, Vicente W, Garcia LV, et al.

Effects of Dexmedetomidine-Fentanyl Infusion on Blood Pressure and Heart Rate during Cardiac Surgery in Children. Anesthesiol Res Pract. 2010;2010. pii: 869049.


Длительная инфузия

Andreolio C, Piva JP, Baldasso E, et al.

Prolonged Infusion of Dexmedetomidine in Critically-ill Children. Indian Pediatr. 2016 Nov 15;53(11):987-989.


Gupta P, Whiteside W, Sabati A, et al.

Safety and efficacy of prolonged dexmedetomidine use in critically ill children with heart disease*.

Pediatr Crit Care Med. 2012; 13(6):660-6.


Burbano NH, Otero AV, Berry DE  et al. 

Discontinuation of prolonged infusions of dexmedetomidine in critically ill children with heart disease. Intensive Care Med. 2012 Feb;38(2):300-7.


Reiter PD, Pietras M, Dobyns EL.

Prolonged dexmedetomidine infusions in critically ill infants and children. Indian Pediatr 2009; 46 (9): 767-73.


Bejian S, Valasek C, Nigro JJ, et al.

Prolonged use of dexmedetomidine in the paediatric cardiothoracic intensive care unit.

Cardiol Young 2009; 19: 98–104.



Mason et al.

Intramuscular Dexmedetomidine: An Effective Route of Sedation Preserves Background Activity for Pediatric Electroencephalograms. J Pediatr 2012; 161: 927-32


Aksu R, Kumandas S, Akin A, et al.

The comparison of the effects of dexmedetomidine and midazolam sedation on electroencephalography in pediatric patients with febrile convulsion.  Paediatr Anaesth 2011; 21: 373-8.


Mason KP,  Mahoney O, Zurakowski D, et al.

Effects of dexmedetomidine sedation on the EEG in children. Paediatr Anaesth. 2009; 19: 1175-83.


Tobias JD, Goble TJ, Bates G et al.

Effects of dexmedetomidine on intraoperative motor and somatosensory evoked potential monitoring during spinal surgery in adolescents.

Paediatr Anaesth. 2008; 18: 1082-8.



Gong M, Man Y, Fu Q.

Incidence of bradycardia in pediatric patients receiving dexmedetomidine anesthesia: a meta-analysis. Int J Clin Pharm. 2017; 39(1): 139-147


Takahashi Y, Ueno K, Ninomiya Y, et al.

Potential risk factors for dexmedetomidine withdrawal seizures in infants after surgery for congenital heart disease.Brain Dev. 2016; 38(7): 648-53.


Lam F, Ransom C, Gossett JM,  et al. 

Safety and efficacy of dexmedetomidine in children with heart failure. Pediatr Cardiol. 2013; 34(4): 835-41.


Carney L, Kendrick J, Carr R .

Safety and Effectiveness of Dexmedetomidine in the Pediatric Intensive Care unit.  Can J Hosp Pharma 2013; 66: 21-27.


Su F & Hammer GB

Dexmedetomidine: pediatric pharmacology, clinical uses and safety. Expert Opin Drug Saf  2011; 10(1): 55-66.


Использование в анестезиологии

Предоперационное применение

Li X, Wang X, Jin S, Zhang D, Li Y.

The safety and efficacy of dexmedetomidine-remifentanil in children undergoing flexible bronchoscopy: A retrospective dose-finding trial. Medicine (Baltimore). 2017; 96(11): e6383. doi: 10.1097/MD.0000000000006383.


Bong CL, Yeo AS, Fabila T1, et al.

A pilot study of dexmedetomidine sedation and caudal anesthesia for inguinal hernia repair in infants. Paediatr Anaesth. 2016; 26(6): 621-7


Lee JS, Wu R, Wong T, et al.

Extended Sedation With Continuous Midazolam or Dexmedetomidine Infusion for Young Children Receiving 131 I-MIBG Radiopharmaceutical Therapy for Advanced Neuroblastoma. Pediatr Blood Cancer. 2016 Mar;63(3):471-8.


El-Shmaa NS, El Amrousy D, El Feky W.

The efficacy of pre-emptive dexmedetomidine versus amiodarone in preventing postoperative junctional ectopic tachycardia in pediatric cardiac surgery. Ann Card Anaesth. 2016; 19(4): 614-620.


Wei L, Deng X, Sui J, et al.

Dexmedetomidine improves intubating conditions without muscle relaxants in children after induction with propofol and remifentanil. Anesth Analg. 2015; 121(3): 785-90.


Phelps Jr, Russell A, Lupa Mc, et al

High-dose dexmedetomidine for noninvasive pediatric procedural sedation and discharge readiness.

Paediatr Anaesth. 2015; 25(9): 877-82.


Gumus H, Bayram Ak, Poyrazoglu Hg, ET AL.

Comparison of effects of different dexmedetomidine and chloral hydrate doses used in sedation on electroencephalography in pediatric patients.

J Child Neurol. 2015; 30(8): 983-8.


Keidan I, Ben-Menachem E, Tzadok M, et al.

Electroencephalography for children with autistic spectrum disorder: a sedation protocol.

Paediatr Anaesth. 2015; 25(2): 200-5.


Yu J, Zhang Y, Lu Y, Dong C.

Preemptive dexmedetomidine to prevent propofol injection pain in children. Ir J Med Sci. 2015; 184(2): 375-8.


Thimmarayappa A, Chandrasekaran N, Jagadeesh AM, et al.

Pediatric cardiac catheterization procedure with dexmedetomidine sedation: radiographic airway patency assessment. Ann Card Anaesth. 2015; 18(1): 29-33.


Ahmed SS, Unland T, Slaven JE et al. 

High Dose Dexmedetomidine: Effective as a Sole Agent Sedation for Children Undergoing MRI

Int J Pediatr. 2015;2015:397372. doi: 10.1155/2015/397372. Epub 2015 Jan 29.


Chen KZ, Ye M, Huet CB, et al.

Dexmedetomidine vs remifentanil intravenous anaesthesia and spontaneous ventilation for airway foreign body removal in children. Br J Anaesth. 2014; 112 (5): 892–7


Mason KP, Robinson F, Fontaine P,  et al. 

Dexmedetomidine offers an option for safe and effective sedation for nuclear medicine imaging in children. Radiology. 2013 Jun; 267(3): 911-7.


McMorrow SP, Abramo TJ. 

Dexmedetomidine sedation: uses in pediatric procedural sedation outside the operating room.

Pediatr Emerg Care. 2012; 28(3): 292-6.


Tobias JD.

Dexmedetomidine and ketamine: an effective alternative for procedural sedation?  Pediatr Crit Care Med 2012; 13: 423–7.


Dilek O, Yasemin G, Atci M.

Preliminary experience with dexmedetomidine in neonatal anesthesia. J Anaesthesiol Clin Pharmacol 2011; 27: 17-22.


Anand VG, Kannan M, Thavamani A, et al.

Effects of dexmedetomidine added to caudal ropivacaine in paediatric lower abdominal surgeries.

Indian J Anaesth. 2011; 55: 340-6.


Siddappa R, Riggins J, Kariyanna S, et al.

High-dose dexmedetomidine sedation for pediatric MRI. Paediatr Anaesth. 2011; 21: 153-8.


Периоперационное применение

Shuplock JM, Smith AH, Owen J, et al

Association between perioperative dexmedetomidine and arrhythmias after surgery for congenital heart disease. Circ Arrhythm Electrophysiol. 2015 Jun;8(3):643-50.


Achuff BJ, Nicolson SC, Elci OU, et al.

Intraoperative dexmedetomidine reduces postoperative mechanical ventilation in infants after open heart surgery. Pediatr Crit Care Med. 2015; 16(5): 440-7


Jiang L, Ding S, Yan H, Li Y et al.

A retrospective comparison of dexmedetomidine versus midazolam for pediatric patients with congenital heart disease requiring postoperative sedation.  Pediatr Cardiol. 2015 Jun; 36(5):993-9.. Epub 2015 Feb 8.


Chrysostomou C, Sanchez-de-Toledo J, Wearden P, et al.

Perioperative use of dexmedetomidine is associated with decreased incidence of ventricular and supraventricular tachyarrhythmias after congenital cardiac operations.  Ann Thorac Surg. 2011;92: 964-72.


Chrysostomou C, Sanchez-de-Toledo , Avolio T et al.

Dexmedetomidine use in a pediatric cardiac intensive care unit: can we use it in infants after cardiac surgery?  Pediatr Crit Care Med. 2009; 10: 654-60.


Easley RB, Brady KM, Tobias JD.

Dexmedetomidine for the treatment of postanesthesia shivering in children.  Paediatr Anaesth. 2007; 17: 341-6



Fang XZ, Gao J, Ge YL,  et al.

Network Meta-Analysis on the Efficacy of Dexmedetomidine, Midazolam, Ketamine, Propofol, and Fentanyl for the Prevention of Sevoflurane-Related Emergence Agitation in Children. Am J Ther. 2016; 23(4): e1032-42.


Hauber JA, Davis PJ, Bendel LP, et al

Dexmedetomidine as a Rapid Bolus for Treatment and Prophylactic Prevention of Emergence Agitation in Anesthetized Children. Anesth Analg. 2015; 121(5): 1308-15.


Kim HS, Byon HJ, Kim JE, et al.

Appropriate dose of dexmedetomidine for the prevention of emergence agitation after desflurane anesthesia for tonsillectomy or adenoidectomy in children: up and down sequential allocation.

BMC Anesthesiol. 2015; 15:79.


Hadi SM, Saleh AJ, Tang YZ, et al

The effect of KETODEX on the incidence and severity of emergence agitation in children undergoing adenotonsillectomy using sevoflurane based-anesthesia. Int J Pediatr Otorhinolaryngol. 2015; 79(5): 671-6.


Kim J, Kim SY, Lee JH et al.

Low-dose dexmedetomidine reduces emergence agitation after desflurane anaesthesia in children undergoing strabismus surgery. Yonsei Med J. 2014 Mar;55(2):508-16. doi: 10.3349/ymj.2014.55.2.508.


Chen JY, Jia JE, Liu TJ, et al.

Comparison of the effects of dexmedetomidine, ketamine, and placebo on emergence agitation after strabismus surgery in children. Can J Anaesth. 2013 Apr;60(4):385-92.


Canpolat DG, Esmaoglu A,  Tosun Z, et al.

Ketamine-Propofol vs Ketamine-Dexmedetomidine Combinations in Pediatric Patients Undergoing Burn Dressing Changes.  J Burn Care Res 2012;33(6):718-22


Другие пути введения

Интраназальное применение

Yang F, Liu Y et al.

Analysis of 17 948 pediatric patients undergoing procedural sedation with a combination of intranasal dexmedetomidine and ketamine. Paediatr Anaesth. 2019 Jan;29(1):85-91


Baier NM, Mendez SS, Kimm D, et al

Intranasal dexmedetomidine: an effective sedative agent for electroencephalogram and auditory brain response testing. Paediatr Anaesth. 2016 Mar;26(3):280-5


Yuen VM, Hui TW, Irwin MG, et al. 

A randomised comparison of two intranasal dexmedetomidine doses for premedication in children

Anaesthesia 2012; 67(11): 1210-6


Yuen VM, Hui TW, Irwin MG, et al.

Optimal timing for the administration of intranasal dexmedetomidine for premedication in children.

Anaesthesia. 2010; 65(9): 922-9


Пероральный путь

Singh C, Pandey RK, Saksena AK, et al.

A comparative evaluation of analgo-sedative effects of oral dexmedetomidine and ketamine: a triple-blind, randomized study. Paediatr Anaesth. 2014; 24(12): 1252-9.


Cimen ZS, Hanci A, Sivrikaya GU, et al.

Comparison of buccal and nasal dexmedetomidine premedication for pediatric patients.

Paediatr Anaesth. 2013; 23(2): 134-8.