Дексмедетомидин на ресурсе PubMed

Дексдор для седации при проведении анестезиологического пособия

Пластическая хирургия

Fan W, Xue H, Sun Y et al. Dexmedetomidine improves postoperative patient-controlled analgesia following radical mastectomy. Front Pharmacol. 2017;8:250.

Taghinia AH, Shapiro FE, Slavin SA. Dexmedetomidine in aesthetic facial surgery: improving anesthetic safety and efficacy. Plast Reconstr Surg. 2008;121:269–76.


Кардиохирургия, сосудистая хирургия

Gallego-Ligorit L, Vives M, Vallés-Torres J, et al. Use of Dexmedetomidine in Cardiothoracic and Vascular Anesthesia. J Cardiothorac Vasc Anesth. 2018;32:1426–38.

Mayr NP, Wiesner G, van der Starre P, et al. Dexmedetomidine versus propofol-opioid for sedation in transcatheter aortic valve implantation patients: a retrospective analysis of periprocedural gas exchange and hemodynamic support. Can J Anaesth. 2018;65:647–57.

Slupe AM, Minnier J, Raitt MH, et al. Dexmedetomidine sedation for paroxysmal supraventricular tachycardia ablation is not associated with alteration of arrhythmia inducibility. Anesth Analg. 2018 Apr 11. [Epub ahead of print].

Khalil M, Al-Agaty A, Asaad O, et al. A comparative study between propofol and dexmedetomidine as sedative agents during performing transcatheter aortic valve implantation. J Clin Anesth. 2016; 32:242–7.

Lee J, Huh U, Song S, et al. Regional anesthesia with dexmedetomidine infusion: a feasible method for the awake test during carotid endarterectomy. Ann Vasc Dis 2016;9:295–9.



Mathews L, Camalier CR, Kla KM , et al. The effects of dexmedetomidine on microelectrode recordings of the subthalamic nucleus during deep brain stimulation surgery: A retrospective analysis. Stereotact Funct Neurosurg. 2017;95:40–8.

Morace R, De Angelis M, Aglialoro E, et al. Sedation with αagonist dexmedetomidine during unilateral subthalamic nucleus deep brain stimulation: A preliminary report. World Neurosurg. 2016; 89:320–8.

Sassi M, Zekaj E, Grotta A, et al. Safety in the use of dexmedetomidine (precedex) for deep brain stimulation surgery: our experience in 23 randomized patients. Neuromodulation. 2013;16:401–6.

Prontera A, Baroni S, Marudi A et al. Awake craniotomy anesthetic management using dexmedetomidine, propofol, and remifentanil. Drug Design, Development and Therapy 2017:11;593–8.

Luo X, Zheng X, Huang H. Protective effects of dexmedetomidine on brain function of glioma patients undergoing craniotomy resection and its underlying mechanism. Clin Neurol Neurosurg. 2016;146:105–8.

Souter MJ, Rozet I, Ojemann JG, et al. Dexmedetomidine sedation during awake craniotomy for seizure resection: effects on electrocorticography. J Neurosurg Anesthesiol. 2007;19:38–44.

Prabhakar H, Mahajan C, Kapoor I. Anesthesia for minimally invasive neurosurgery. Curr Opin Anaesthesiol. 2017;30:546–50.

Tsaousi GG, Lamperti M, Bilotta F. Role of dexmedetomidine for sedation in neurocritical care patients: A qualitative systematic review and meta-analysis of current evidence. Clin Neuropharm 2016;39:144–51.

Ho KM. Is dexmedetomidine an ideal sedative agent for neurosurgical patients? Anaesth Intensive care 2012;40:927–8.


Травма и ортопедия

Kumar G, Dubey PK, Sanjeev OP. Effect of midazolam and dexmedetomidine sedation on the onset and duration of supraclavicular brachial plexus block: A randomised comparative study. Turk J Anaesthesiol Reanim. 2018;46:201–7.

Shin HJ, Do SH, Lee JS, et al. Comparison of intraoperative sedation with dexmedetomidine versus propofol on acute postoperative pain in total knee arthroplasty under spinal anesthesia: A randomized trial. Anesth Analg. 2018 Apr 5. [Epub ahead of print].

Chan IA, Maslany JG, Gorman KJ et al. Dexmedetomidine during total knee arthroplasty performed under spinal anesthesia decreases opioid use: a randomized–controlled trial. Can J Anaesth. 2016;63:569–76.

Lee JM, Lee SK, Lee SJ et al. Comparison of remifentanil with dexmedetomidine for monitored anaesthesia care in elderly patients during vertebroplasty and kyphoplasty. J Int Med Res. 2016;44:307–16.

Peng K, Liu HY, Liu SI et al. Dexmedetomidine-fentanyl compared with midazolam-fentanyl for conscious sedation in patients undergoing lumbar disc surgery. Clin Ther. 2016;38:192–201.


Бариатрическая хирургия

Singh PM, Panwar R, Borle A et al. Perioperative analgesic profile of dexmedetomidine infusions in morbidly obese undergoing bariatric surgery: a meta-analysis and trial sequential analysis. Surg Obes Relat Dis. 2017;13:1434–46.

Aub-Halaweh S, Obeidat F, Absalom AR et al. Dexmedetomidine versus morphine infusion following laparoscopic bariatric surgery: effect on supplemental narcotic requirement during the first 24 h. Surg Endosc. 2016;30:3368–74.


Интубация в сознании/Бронхоскопия

Niyogi S, Basak S, Acharjee A, Chakraborty I. Efficacy of intravenous dexmedetomidine on patient’s satisfaction, comfort and sedation during awake fibre-optic intubation in patients with cervical spondylotic myelopathy posted for elective cervical fixation. Indian J Anaesth.2017; 61:137–43.

Sharma J, Purohit S, Bhatia S, et al. Awake orotracheal fibre-optic intubation: Comparison of two different doses of dexmedetomidine on intubation conditions in patients undergoing cervical spine surgery. Indian J Anaesth. 2017;61:811–7.

Chopra P, Dixit MB, Dang A, Gupta V. Dexmedetomidine provides optimum conditions during awake fiberoptic intubation in simulated cervical spine injury patients. J Anaesthesiol Clin Pharmacol. 2016;3:54–8.


Абдоминальная хирургия

Li HJ, Li CJ, Wei XN, et al. Dexmedetomidine in combination with morphine improves postoperative analgesia and sleep quality in elderly patients after open abdominal surgery: A pilot randomized control trial. PLoS One. 2018;13:e0202008.

Jessen Lundorf L, Korvenius Nedergaard H, Moller AM. Perioperative dexmedetomidine for acute pain after abdominal surgery in adults. Cochrane Database Syst Rev. 2016;2:CD010358.

Wallace S, Mecklenburg B, Hanling S. Profound reduction in sedation and analgesic requirements using extended dexmedetomidine infusions in a patient with an open abdomen. Mil Med. 2009;174:1228–30.



Kinugasa H, Higashi R, Myiyahara K, et al. Dexmedetomidine for conscious sedation with colorectal endoscopic submucosal dissection: a prospective double-blind randomized controlled study. Clin Transl Gastroenterol. 2018;9:167.

Lu Z , Li W, Chen H, Qian Y. Efficacy of a dexmedetomidine-remifentanil combination compared with a midazolam-remifentanil combination for conscious sedation during therapeutic ERCP: a prospective, randomized, single-blinded preliminary trial. Dig Dis and Sci. 2018;63:1633–40.

Viana A, Zhao C, RosaT, et al. The effect of sedative agents on drug-induced sleep endoscopy findings. Laryngoscope. 2018 Sep 7. [Epub ahead of print].

Chang ET, Certal V, Song SA, et al. Dexmedetomidine versus propofol during drug-induced sleep endoscopy and sedation: a systematic review. Sleep Breath. 2017;21:727–35.

Nishizawa T, Suzuki H, Hosoe N, et al. Dexmedetomidine vs propofol for gastrointestinal endoscopy: A meta-analysis . United European Gastroenterol J. 2017;5:1037–45.



Nagy AA, El-Sayd SH, Ahmed AA, Rajab GZ. Optimal dose of dexmedetomidine retrobulbar anesthesia during phacoemulsification cataract surgery. Anesth Essays Res. 2017;11:1046–50.

Yoo JH, Kim SI, Cho A, et al. The effect of dexmedetomidine sedation on patient and surgeon satisfaction during retinal surgery under sub-tenon’s anesthesia: a randomized controlled trial. Korean J Anesthesiol. 2015;68:442–8.



Singh V, Thepra M, Kirti S, et al. Dexmedetomidine as an additive to local anesthesia: a step to development in dentistry. J Oral Maxillofac Surg. 2018;76:2091.e1-2091.e7.

Togawa E, Hanamoto H, Maegawa H, et al. Dexmedetomidine and midazolam sedation reduces unexpected patient movement during dental surgery compared with propofol and midazolam sedation. J Oral Maxillofac Surg. 2018 Jul 10. pii: S0278– 2391(18)30761–4.

Kumar P, Thepra M, Bhagol A, et al. The newer aspect of dexmedetomidine use in dentistry: As an additive to local anesthesia, initial experience, and review of literature. Natl J Maxillofac Surg. 2016;7:76–9.



Qin M, Chen K, Liu T, Shen X. Dexmedetomidine in combination with sufentanil for postoperative analgesia after partial laryngectomy. BMC Anesthesiol. 2017;17:66.

Liu T, Qin M, Li W, Shen X. Effects of a single dose dexmedetomidine on surgical field visibility during middle ear microsurgery: A randomized study. Otol Neurotol. 2016;37:680–4.

Kavalci G, Ethemoglu FB, Durukan P, et al. Comparison of the effects of dexmedetomidine and remiphentanyl on emergence agitation after sevoflurane anesthesia in adults undergoing septoplasty operation: a randomized double-blind trial. Eur Rev Med Pharmacol Sci. 2013;17:3019–23.


Акушерство и Гинекология

Han C, Ge SJ, Huang SQ, et al. Influence of different menstrual phases on the Bispectral Index during dexmedetomidine sedation. Kaohsiung J Med Sci. 2016;32:586–92.

Wang X, Wang K, Wang B, et al. Effect of dexmedetomidine alone for intravenous patient-controlled analgesia after gynecological laparoscopic surgery: A consort-prospective, randomized, controlled trial. Medicine (Baltimore). 2016;95:e3639.

Jung HS, Joo JD, Jeon YS, et al. Comparison of an intraoperative infusion of dexmedetomidine or remifentanil on perioperative haemodynamics, hypnosis and sedation, and postoperative pain control. J Int Med Res. 2011;39:1890–9.



Shamim R, Srivastava S, Rastogi A, et al. Effect of two different doses of dexmedetomidine on stress response in laparoscopic pyeloplasty: A randomized prospective controlled study. Anesth Essays Res. 2017;11:1030–4.

Kose EA, Honca M, Yilmaz E, et al. Comparison of effects of dexmedetomidine-ketamine and dexmedetomidine-midazolam combinations in transurethral procedures. Urology 2012;9:1214–9.


 Дексдор для седации в ОРИТ

Согласительные документы

Седация пациентов на неинвазивной вентиляции легких (НИВ):
Longrois D, Conti G, Mantz J, et al. 
Sedation in Non-Invasive Ventilation: Do we know what to do (and why)? Multidisciplinary Respiratory Medicine. 2014;9:56

Седация пациентов ОРИТ с морбидным ожирением
Aantaa R, Tonner P, Conti G, et al. 
Sedation options for the morbidly obese intensive care unit patient: a concise survey and an agenda for development. Multidiscip Respir Med. 2015;10:8.

Седация и отлучение от ИВЛ

Conti G, Mantz J, Longrois D, Tonner P. 

Sedation and weaning from mechanical ventilation: time for ‘best practice’ to catch up with new realities? Multidisciplinary Respiratory Medicine.  2014;9:45.


Dong CS, Lu Y, Zhang J, et al.
The optimal dose of dexmedetomidine added to an sufentanil-based analgesic regimen for postoperative pain control in spine surgery. 
A probit analysis study, Medicine (Baltimore). 2016;95:e4776.
Song J, Ji Q, Sun Q, et al.
The Opioid-sparing Effect of Intraoperative Dexmedetomidine Infusion After Craniotomy. 
J Neurosurg Anesthesiol. 2016;28:14–20.

Tsaousi GG, Lamperti M, Bilotta F.
Role of Dexmedetomidine for Sedation in Neurocritical Care Patients: A Qualitative Systematic Review and Meta-analysis of Current Evidence. 
Clin Neuropharm. 2016;39:144–51.

Erdman MJ, Doepker BA, Gerlach AT, et al.
A comparison of severe hemodynamic disturbances between dexmedetomidine and propofol for sedation in neurocritical care patients. 
Crit Care Med. 2014;42:1696–702.

Srivastava VK, Agrawal S, Kumar S, et al.   
Comparison of Dexmedetomidine, Propofol and Midazolam for Short-Term Sedation in Postoperatively mechanically Ventilated Neurosurgical Patients. 
J Clin Diagn Res. 2014;8:GC04–7.

Wang X, Ji J, Fen L, Wang A.
Effects of dexmedetomidine on cerebral blood flow in critically ill patients with or without traumatic brain injury: a prospective controlled trial. 
Brain Inj. 2013;27:1617–22.

Drummond JC, Sturaitis MK.
Brain tissue oxygenation during dexmedetomidine administration in surgical patients with neurovascular injuries. 
J Neurosurg Anesthesiol. 2010;22:336–41.



Cho JS, Shim JK, Soh S, et al.
Perioperative dexmedetomidine reduces the incidence and severity of acute kidney injury following valvular heart surgery. 
Kidney Int. 2016;89:693–700.

Djaiani G, Silverton N, Fedorko L, et al. 
Dexmedetomidine versus Propofol Sedation Reduces Delirium after Cardiac Surgery: A Randomized Controlled Trial. Anesthesiology. 2016;124:362–8.

Karaman Y, Abud B, Tekgul ZT, et al.
Effects of dexmedetomidine and propofol on sedation in patients after coronary artery bypass graft surgery in a fast-track recovery room setting. 
J Anesth. 2015;29:522–8.

Zhang X, Zhao W, Wang Y.
Dexmedetomidine: a review of applications for   cardiac surgery during perioperative period. J Anesth. 2015;29:102–11.

Ji F, Li Z, Young N, et al.
Perioperative Dexmedetomidine Improves Mortality in Patients Undergoing Coronary Artery Bypass Surgery. 
J Cardiothorac Vasc Anesth. 2014;28:267–73.
Maldonado JR, Wysong A, van der Starre PJ, et al. 
Dexmedetomidine and the reduction of postoperative delirium after cardiac surgery.  Psychosomatics. 2009;50:206–17.

Herr DL, Sum-Ping ST, England M.
ICU sedation after coronary artery bypass graft surgery: dexmedetomidine-based versus propofol- based sedation regimens. 
J Cardiothorac Vasc Anesth. 2003;17:576–84.


Неинвазивная вентиляция легких

Longrois D, Conti G, Mantz J, et al.
Sedation in Non-Invasive Ventilation: Do we know what to do (and why)? 
Multidisciplinary Respiratory Medicine. 2014;9:56

Demuro JP, Mongelli MN, Hanna AF.
Use of dexmedetomidine to facilitate non-invasive ventilation. 
Int J Crit Illn Inj Sci. 2013;3:274–5.

Huang Z, Chen YS, Yang ZL, Liu J.
Dexmedetomidine versus midazolam for the sedation of patients with non-invasive ventilation failure. 
Intern Med. 2012;51:2299–305.

Senoglu N, Oksuz H, Dogan Z, et al.
Sedation during noninvasive mechanical ventilation with dexmedetomidine or midazolam: a randomized, double-blind, prospective study. 
Curr Ther Res. 2010;71:141–53.